Stellar mass-SFR plane for galaxies between 4 ≲ z ≲ 6. The CRISTAL sample consists of 39 star-forming galaxies between 4 ≲ z ≲ 6 that are representative of the population of massive (M_⋆ ≳ 10⁹ M_⊙) galaxies at this redshift range. CRISTAL galaxies are shown as green circles, color-coded according to their redshift. The main sequence of star-forming galaxies at z = 5 is shown following the calibrations by Speagle et al. (2014) (with ±0.5 dex width represented by the shaded orange region), Schreiber et al. (2015), and Khusanova et al. (2021). Galaxies from the pilot programs and drawn from the archive are shown as squares. SMGs in the CRISTAL fields are shown as stars. Star-forming galaxies detected in [C II] line emission observed as part of the ALPINE survey (Le Fèvre et al. 2020; Béthermin et al. 2020; Faisst et al. 2020a) are shown as gray circles.