Permutation test scores. The red dashed line indicates the cross-validated F₂-score of our RF classifier on the training data. The blue histogram shows the cross-validated F₂-score of our RF classifier on the training data when the corresponding labels are randomly permuted. We repeated the shuffling of the labels and cross-validated score assessment 1000 times with different random seeds. The difference between the scores for the permuted data and those for the original data indicates the significance of our trained model.