Γ vs. λ_Edd for a compilation of local or high-λ_Edd AGN and high-redshift luminous QSOs. Red stars are the HYPERION QSOs presented in this work. Green four-pointed stars are other z > 6 QSOs detected with ≳30 net counts from the X-ray spectral analysis performed by Vito et al. (2019) and not included in the HYPERION sample. Quasars at Cosmic Noon (z = 2 − 4) are reported as purple triangles (the WISSH QSOs from Zappacosta et al. 2020), empty cyan circles (Shemmer et al. 2006a, 2008), and pink diamonds (Nardini et al. 2019; Trefoloni et al. 2023). Local high-λ_Edd QSOs (Laurenti et al. 2022) and local AGN including Narrow Line Seyfert 1 (NLSy1s) galaxies (Liu et al. 2021) are shown as blue squares and yellow circles, respectively. Reported are also the most recent relations from a linear fit to the local AGN (i.e., Trakhtenbrot et al. 2017; Liu et al. 2021). The uncertainties on λ_Edd from QSOs with M_BH estimated using a single-epoch virial mass estimator are dominated by systematic uncertainties and can be as high as 0.5 dex. The statistical uncertainty on λ_Edd for the local AGN (Liu et al. 2021) whose masses are estimated via reverberation mapping is 0.1 dex and 0.2 dex for the sub-Eddington and super-Eddington sources, respectively.