Gibbs free-energy (kcal mol⁻¹) profiles of pre-qualified reactions for three regions of IRAS 16293 astrophysical conditions at CCSD(T)-F12/cc-pVTZ-F12 (corrections for ZPE incorporated). Region I: T_gas = 20 K and P_gas = 2.29 × 10⁷ K cm⁻³. Region II:. T_gas = 80 K and P_gas = 7.06 × 10⁷ K cm⁻³. Region III: T_gas = 150 K and P_gas = 6.08 × 10⁸ K cm⁻³. Energy unitsof ΔH°, ΔG° in kcal mol⁻¹; ΔS° in cal mol⁻¹ K⁻¹. In parentheses, we plot the net charge and spin multiplicity.