Iterated t-SNE plane. The values of t-SNE X and t-SNE Y from Figure 1 in the central panel were fed as additional data to another run of t-SNE, so as to check if adjacent groups in the original t-SNE plane were separated or not, and to determine where the borders occur. It is important to notice how the overall shape is kept, but in fact in this case t-SNE flipped the orientation of the points in the plane.