Statistical (i.e. taking into account the statistical ratios for the functional groups with multiple H-atoms) CH₂ DOH (top left), CH₃OD (top right), HDO (bottom left), and CH₂DCN (bottom right) deuterium fractionations observed towards the hot core of a sample of low-mass (red), intermediate-mass (blue), and high-mass (green) protostars with sub-millimeter interferometers as function of the dust temperature of the surrounding cloud measured with the Herschel or Planck telescopes (see values in Table 3).