Comparison of AFM-IR and O-PTIR (mIRage^®) spectra of nanoglobule-like inclusions from this study with IR spectra of some macromolecular residues from Muñoz Caro & Schutte (2003), obtained after irradiation of interstellar ice analogues and annealing to room temperature. These irradiation experiments simulate the physical conditions in dense clouds and the accretion and photoprocessing of ices on grain surfaces.