Offset to the Speagle et al. (2014) galaxy main sequence vs. gas depletion time in Myr. The solid lines indicate the scaling relations of Scoville et al. (2017), Tacconi et al. (2018, 2020), Liu et al. (2019), Kokorev et al. (2021) normalized to z = 4.3 and log(M_⋆ [Ṁ]) = 10.67. CGG-z4.a and CGG-z4.b are shown as magenta diamonds, SPT2349-56 galaxies are shown as green squares (Miller et al. 2018; Hill et al. 2020, 2022), GN20 galaxies are shown as red circles (Tan et al. 2014), and the Jin et al. (2019, 2022) galaxies are shown as orange diamonds. Depletion timescales were calculated for the SPT2349-56 galaxies using a gas mass with an α_CO = 1.0 and a CO(4–3)/CO(1–0) line ratio r₄₁ = 0.6 ± 0.05 (Spilker et al. 2014). The gas masses of each GN20 galaxy were calculated using the average of α_CO derived from the gas-to-dust mass ratio method and dynamical modeling. The gas masses for the galaxies of Jin et al. (2019, 2022) were estimated from [CI](1–0) line data in each paper.